Naturally Occurring Scrapie in Southdown Sheep
نویسندگان
چکیده
منابع مشابه
Pathological prion protein in the tongues of sheep infected with naturally occurring scrapie.
Tongue involvement by prion spreading was shown to be a common outcome after oral or intracranial experimental challenge with scrapie and transmissible mink encephalopathy sources in rodent models. It is also known that bovine spongiform encephalopathy, which is pathogenic for humans, is experimentally transmissible to sheep and can lead to a disease indistinguishable from scrapie. A recent Eur...
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Accumulation of prion protein (PrPSc) in the central nervous system is the hallmark of transmissible spongiform encephalopathies. However, in some of these diseases such as scrapie or chronic wasting disease, the PrPSc can also accumulate in other tissues, particularly in the lymphoreticular system. In recent years, PrPSc in organs other than nervous and lymphoid have been described, suggesting...
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AAV vectors have shown great promise for clinical gene therapy (GT), but pre-existing human immunity against the AAV capsid often limits transduction. Thus, testing promising AAV-based GT approaches in an animal model with similar pre-existing immunity could better predict clinical outcome. Sheep have long been used for basic biological and preclinical studies. Moreover, we have re-established ...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 1999
ISSN: 0891-6640,1939-1676
DOI: 10.1111/j.1939-1676.1999.tb02181.x